2021.10.26 06:29 Fuxitadventure I just got a position! Start date march 13th!
Man, I almost gave up on the whole wildland firefighting idea until yesterday. The hard work payed off I finally sunk a position on a engine module in New Mexico.
submitted by Fuxitadventure to Wildfire [link] [comments]
2021.10.26 06:29 svanapps r/cardano - How to track balance with 3rd part trackers?
2021.10.26 06:29 Ricosss Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy. (Pub Date: 2021)
The Warburg effect, also termed "aerobic glycolysis", is one of the most remarkable and ubiquitous metabolic characteristics exhibited by cancer cells, representing a potential vulnerability that might be targeted for tumor therapy. Ketogenic diets (KDs), composed of high-fat, moderate-protein and low carbohydrates, are aimed at targeting the Warburg effect for cancer treatment, which have recently gained considerable attention. However, the efficiency of KDs was inconsistent, and the genotypic contribution is still largely unknown.
The bulk RNA-seq data from The Cancer Genome Atlas (TCGA), single cell RNA sequencing (scRNA-seq), and microarray data from Gene Expression Omnibus (GEO) and Cancer Cell Line Encyclopedia (CCLE) were collected. A joint analysis of glycolysis and ketone bodies metabolism (KBM) pathway was performed across over 10,000 tumor samples and nearly 1,000 cancer cell lines. A series of bioinformatic approaches were combined to identify a metabolic subtype that may predict the response to ketogenic dietary therapy (KDT). Mouse xenografts were established to validate the predictive utility of our subtypes in response to KDT.
We first provided a system-level view of the expression pattern and prognosis of the signature genes from glycolysis and KBM pathway across 33 cancer types. Analysis by joint stratification of glycolysis and KBM revealed four metabolic subtypes, which correlated extensively but diversely with clinical outcomes across cancers. The glycolytic subtypes may be driven by TP53 mutations, whereas the KB-metabolic subtypes may be mediated by CTNNB1 (β-catenin) mutations. The glycolytic subtypes may have a better response to KDs compared to the other three subtypes. We preliminarily confirmed the idea by literature review and further performed a proof-of-concept experiment to validate the predictive value of the metabolic subtype in liver cancer xenografts.
Our findings identified a metabolic subtype based on glycolysis and KBM that may serve as a promising biomarker to predict the clinical outcomes and therapeutic responses to KDT.
submitted by Ricosss to ketoscience [link] [comments]
2021.10.26 06:29 lupoman999 how this token work??
2021.10.26 06:29 n294 phone bill
2021.10.26 06:29 Wicked2707 Little fur baby cuddles <3
|submitted by Wicked2707 to cats [link] [comments]|
2021.10.26 06:29 123_dave Strange vision in Infinity War
So after what we see in Loki, what did strange see in Infinity War? And if the avengers took the gems from the past, shouldn't the TVA intervene?
submitted by 123_dave to MarvelTheories [link] [comments]
2021.10.26 06:29 igshahil Anybody knows the name of this girl ?
2021.10.26 06:29 SirEntityTheGreat Fear The Walking Dead | S7:E3 "Cindy Hawkins" | Reaction & Discussion!
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submitted by Necessary-Eye-2249 to CryptoMars [link] [comments]
2021.10.26 06:29 recumbentrambler Walking the dog - another job for the recumbent trike
Our adult son is staying with us for a while. His dog needs walking, and as I ride every day on my Greenspeed Magnum, it fell to me to walk her. It turns out that a recumbent trike provides the best means to walk a large dog. I can sit back, relax and listen to an audiobook when she wants a long sniff, I can make her run for cardio, and we can do the distance she needs. So, I wrote a blog article about it. Let me know what you think.Recumbent Rambler Dog Walking Blog
submitted by recumbentrambler to recumbent [link] [comments]
2021.10.26 06:29 Ready-Common3069 Darkrai on me 0696 6063 1730
2021.10.26 06:29 HowkinsW Anime_irl
2021.10.26 06:29 Pureenus My partner's requiring help but does not have a Medicare card nor any insurance. Where can I recommend her to in Sydney that's not too overpriced?
2021.10.26 06:29 NDHoangMinh Internet speed problem!!!
Recently i had alot of problems with my game, unlike any other game like ER:LC or PTFS run smoothly. Now my main question is does this happen for every1 or its just me. (its not high ping lag its huge lag spike. Dont tell me about the server region, i alway join by PF Hub.)
submitted by NDHoangMinh to PhantomForces [link] [comments]
2021.10.26 06:29 hacker_backup Welcome to Anon Reddit, this is (probably) the only place on reddit where you can comment and post without showing your username to other users. You can never be sure who made this post.
2021.10.26 06:29 Electrical_Prune6545 Wow
|submitted by Electrical_Prune6545 to ShitLiberalsSay [link] [comments]|
2021.10.26 06:29 ruditumprolakl Join
2021.10.26 06:29 memrplus What is going on?
I recently found out that i had far cry 6 downloaded on the wrong disc so i uninstalled it from epic games and installed it again. I launched the game and i got instantly redirected to ubisoft connect and it's saying that i need to download it AGAIN. But it al ready downloaded a 50 gb far cry 6 from Epic. How do i fix this
submitted by memrplus to farcry [link] [comments]
2021.10.26 06:29 RLCD-Bot [Octane] [Tidal Stream] [Titanium White Synthwave] [Black Mandala: Infinite]
|submitted by RLCD-Bot to RLCustomDesigns [link] [comments]|
2021.10.26 06:29 Many-Ad4736 Looking for manager
Good day Managers! I am looking for scholarship. Hard working and willing to dedicate my time playing axie everyday.
Name:Julius Garcia Age: 21 Gender: Male Location:Philippines Civil Status: Single Nationality: Filipino Device: AndroidPhone Connection: Mobile Data/Wifi Average SLP per day: 150-200
How many hours per day can you dedicate to playing Axie: I can play 8-10 hours a day.
Do you already have experience playing Axie Infinity: None, but i am willing to learn, research about Axie mechanics and to be educate and im a fast learner too.
Gaming Experience: Call Of Duty Mobile, Clash Of Clans, Mobile legends
Why should you hire me? - In this time of pandemic I'm looking for alternatives to help my family to support them in our financial needs and to pay bills while doing my passion of gaming I hope you'll give me a chance to be one of your scholars and I assure you that I will put my best and effort on it. Thank You!
submitted by Many-Ad4736 to AxieScholarshipsPH [link] [comments]
2021.10.26 06:29 Asgardus Folge der Spur von THE LÄND
|submitted by Asgardus to stuttgart [link] [comments]|
2021.10.26 06:29 ButterscotchDry6762 I do even knew this cat is green. Yeah he is green
2021.10.26 06:29 l0st6666 Where am I?
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2021.10.26 06:29 FlyingNetch ich_iel